Ribbon structure of IGF-1

Nurture Their Growth by
Replacing IGF-1

IGF-1:

Is produced in response to stimulation by growth hormone¹
Directly stimulates the multiple processes leading to growth¹

In target tissues, the Type 1 IGF-1 receptor, which is homologous to the insulin receptor, is activated by IGF-1, leading to intracellular signaling and the growth cascade.¹

Induces the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues.

35% of growth is
regulated by IGF-1, 34% of growth is regulated by both growth hormone and IGF-1, 14%
of growth is regulated by growth hormone alone, 17% of growth is unrelated to either

IGF-1 is the primary mediator of growth ³

*Study based on animal data

1. Increlex [package insert]. Brisbane, Calif. Tercica; 2005.

2. Data on file. Brisbane, Calif. Tercica; 2005.

3. Lupu F, Terwilliger JD, Lee K, et al. Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol. 2001; 229: 141- 162.

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Ribbon structure of IGF-1

IGF-1:

IGF-1 is the primary mediator of growth 3

IGF-1 is the primary mediator of growth ³