Dosing and Storage Information for your Patients¹

Multidose vial can be used and stored for 30 days after first use.
Store Increlex between 35° to 46°F (2° to 8°C) for 30 days after you start using the vial.
Do not freeze Increlex.
Dosage should be individualized. Recommended starting dosage is 0.04 to 0.08 mg/kg (40 to 80 g/kg) twice daily by subcutaneous injection. If well tolerated for at least 1 week, dose may be increased by 0.04 mg/kg per dose, to the maximum dose of 0.12 mg/kg given twice daily.
Increlex should be administered shortly before or shortly after a meal or snack. If the patient is unable to eat shortly before or shortly after a dose for any reason, that dose of Increlex should be withheld.
Subsequent doses of Increlex should never be increased to make up for one or more omitted dose.
Preprandial glucose monitoring should be considered at treatment initiation and until a well-tolerated dose is established. If frequent symptoms of hypoglycemia occur, preprandial glucose monitoring should continue. If hypoglycemia occurs with recommended doses, despite adequate food intake, the dose should be reduced.
Increlex injection sites should be rotated to a different site with each injection.
Increlex should be administered using sterile disposable syringes and needles.

Increlex [package insert]. Brisbane, Calif. Tercica; 2005.
Data on file. Brisbane, Calif. Tercica;2005.
Lupu F, Terwilliger JD, Lee K, et al. Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol. 2001;229:141-162.

Dosing and Storage Information for your Patients1